ARINE-GM: It activates cartilage repair in osteoarthritis. It also slow down the the breakdown of  cartilage and relieve pain and swelling. Reduces Functional imapairment and pain.

Diacerein, also known as diacetylrhein, is a slow-acting medicine of the class anthrquinone used to treat joint diseases such as osteoarthritis (swelling and pain in the joints).Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling.

Glucosamine is a naturally occurring chemical found in the human body. It is in the fluid around joints. Glucosamine also exists in other places in nature.Glucosamine is marketed as a supplement to support the structure and function of joints, and the marketing is targeted to people suffering from osteoarthritis. Glucosamine is a chemical found in the human body. It is used by the body to produce other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints.Joints are cushioned by the fluid and cartilage that surround them. In some people with osteoarthritis, the cartilage breaks down and becomes thin. This results in more joint friction, pain, and stiffness. Researchers think that taking glucosamine supplements may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both.Most research shows that taking glucosamine sulfate can provide some pain relief for people with osteoarthritis, especially those with osteoarthritis of the knees.

Methylsulfonylmethane (MSM) is a chemical found in green plants, animals, and humans. It can also be made in a laboratory.Research shows that taking MSM by mouth in two to three divided doses daily, either alone or together with glucosamine, can slightly reduce pain and swelling and improve function in people with osteoarthritis.

Egg Shell Membrane:

Eggshell Membrane is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium. Itis a possible new effective and safe therapeutic option for the treatment of pain and inflexibility associated with joint and connective tissue (JCT) disorders. Eggshell Membrane 500 mg taken once daily, significantly reduced pain, both rapidly (seven days) and continuously (30 days). It also showed clinically meaningful results from a brief responder analysis, demonstrating that significant proportions of treated patients may be helped considerably from Eggshell Membranesupplementation.

Collagen peptidase:

Collagen helps maintain the integrity of your cartilage, which is the rubber-like tissue that protects your joints.As the amount of collagen in your body decreases as you get older, your risk of developing degenerative joint disorders such as osteoarthritis increases.Some studies have shown that taking collagen supplements may help improve symptoms of osteoarthritis and reduce joint pain overall.

In one study, 73 athletes who consumed 10 grams of collagen daily for 24 weeks experienced a significant decrease in joint pain while walking and at rest, compared with a group that did not take it in another study, adults took 2 grams of collagen daily for 70 days. Those who took collagen had a significant reduction in joint pain and were better able to engage in physical activity than those who did not take it.

Glucosamine Sulphate 500 mg:

Glucosamine sulphate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints.

Joints are cushioned by the fluid and cartilage that surround them. In some people with osteoarthritis, the cartilage breaks down and becomes thin. This results in more joint friction, pain, and stiffness. Researchers think that taking glucosamine supplements may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both.

Hyaluronic Acid 20 mg:

The FDA has approved the use of hyaluronic acid for patients with knee osteoarthritis.body makes hyaluronic acid. It's a natural part of the fluid that helps lubricate and cushion your joints and keeps them working smoothly.

Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have just been added to the market. A comprehensive search was conducted through several search databases according our inclusion and exclusion criteria. This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis.

Curcumin extract:

In the study, researchers enrolled 139 people with symptoms of knee osteoarthritis. Their symptoms were at least moderately severe and required treatment with a nonsteroidal anti-inflammatory drug (NSAID). For one month, they were given the NSAID diclofenac (50 mg, twice daily) or curcumin (500 mg, three times daily).

curcuminis a naturally occurring substance, found in the spice turmeric, that has anti-inflammatory effects. Its use has been advocated for cardiovascular health, arthritis, and a host of other conditions. 

Boswellia extract:

Boswellia, also known as Indian frankincense, is an herbal extract taken from the Boswellia serrata tree. Resin made from Boswellia extract has been used for centuries in Asian and African folk medicine. It’s believed to treat chronic inflammatory illnesses as well as a number of other health conditions.